これ、面白い。 急激にDOCK6の発現を低下させた時と、ノックアウトした時では、後者では適応してしまってフェノタイプが薄れてしまう、というもの。しかも特定の蛋白質を突き止めてそれを操作すると、急激に減少させた時と同じになる、というところまで出し…
PMID: 27210752 Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Mahajan VS, Demissie E, Mattoo H, Viswanadham V, Varki A, Morris R1, Pillai S. Ce…
PMID: 23592719 Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Côté JF. Proc Nat…
PMID: 23525077 Nat Genet. 2013 Apr 26;45(5):478-86. doi: 10.1038/ng.2591. Epub 2013 Mar 24.Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Dana-Farber、MIT、Harvar…
PMID: 23615608Nature. 2013 Apr 24. doi: 10.1038/nature12135. [Epub ahead of print]Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelov…
PMID: 19286668Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling. Sadikovic B, Yoshimoto M, Chilton-MacNeill S, Thorner P, Squire JA, Zielenska M. Hum Mol Ge…
PMID: 16939397 Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. Brazier H, Stephens S, Ory S, Fort P, Morrison N, Blangy A. J Bone Miner Res. 2006 Se…
PMID: 21542010 The Rac1 Exchange Factor Dock5 Is Essential for Bone Resorption by Osteoclasts Vives V, Laurin M, Cres G, Larrousse P, Morichaud Z, Noel D, Côté JF, Blangy A. J Bone Miner Res. 2011 May;26(5):1099-110フランスのラボから。Jean…